Cover Image | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Cover Image

Publication year - 2019

Publication title -

biopolymers

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 0.556

H-Index - 125

eISSN - 1097-0282

pISSN - 0006-3525

DOI - 10.1002/bip.23322

Subject(s) - dendrimer , peg ratio , cover (algebra) , chemistry , hela , image (mathematics) , in vitro , information retrieval , nanotechnology , computer science , microbiology and biotechnology , world wide web , biochemistry , artificial intelligence , materials science , business , engineering , biology , mechanical engineering , finance

Ho et al. report the preparation of PEGylated generation 3.5 and 4 polyamidoamine dendrimers (G3.5‐PEG and G4‐PEG). Both systems are spherical with a diameter less than 100 nm. These dendrimeric materials can encapsulate oxaliplatin (OXA), with an average drug loading efficiency of 75.69% and 84.63%, respectively. In vitro studies show the release of 46.25% of free OXA after an hour, compared to 11.94% from G3.5‐PEG@OXA and 3.40% from G4‐PEG@OXA. Moreover, despite the low release, after 48 hours the killing effect of G4‐PEG@OXA on HELA cells was similar to that of free OXA. (DOI: 10.1002/bip.23272 )

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research