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Publication year - 2020
Publication title -
biopolymers
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.23313
Subject(s) - nucleobase , base pair , cover (algebra) , chemistry , circular dichroism , rna , stereochemistry , image (mathematics) , dna , citation , purine , crystallography , computational biology , computer science , biochemistry , artificial intelligence , world wide web , enzyme , biology , gene , mechanical engineering , engineering
The Resendiz and Wang teams report the base pairing preferences of canonical and modified purine‐based nucleobases within duplexes of RNA. Using circular dichroism and density functional theory, the teams probed the thermal stability and H‐bonding interactions of the purine nucleobases G, I, A, and the corresponding 8‐oxo‐7,8‐dihydropurine and 8‐bromopurine derivatives, 8‐oxoG, 8‐oxoI, 8‐oxoA, 8‐BrG, and 8‐BrI as they form base pairs within an A‐form helix. The data helps aid our understanding of RNA lesions caused by oxidative stress and could be of use in the design of other nucleoside‐based structural motifs or biomaterials. (DOI: 10.1002/bip.23410 )