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Author(s) -
Serena Bertoni,
Ariella Machness,
Mattia Tiboni,
Raquel Bártolo,
Hélder A. Santos
Publication year - 2020
Publication title -
biopolymers
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.23291
Subject(s) - cover (algebra) , citation , medicine , computer science , world wide web , mechanical engineering , engineering
Common pharmacological therapies for gastrointestinal diseases, e.g., inflammatory bowel diseases, irritable bowel syndrome and colon cancer, continue to show challenges in targeting efficacy. Moreover, current conventional oral therapies present different adverse effects associated with systemic exposure. Bertoni et al . summarize innovative approaches to overcoming these drawbacks using disease‐targeted drug delivery systems, including the production and characterization of the nanoplatforms. The smart nanomaterials described respond to increased levels of reactive oxygen species (ROS) concentrated in the inflamed areas, as well as to other more commonly used stimuli, for instance variation of pH value. (DOI: 10.1002/bip.23336 )