Premium
Peptoids advance multidisciplinary research and undergraduate education in parallel: Sequence effects on conformation and lipid interactions
Author(s) -
Jimenez Christian J.,
Tan Jiacheng,
Dowell Kalli M.,
Gadbois Gillian E.,
Read Cameron A.,
Burgess Nicole,
Cervantes Jesus E.,
Chan Shan,
Jandaur Anmol,
Karanik Tara,
Lee Jaenic J.,
Ley Mikaela C.,
McGeehan Molly,
McMonigal Ann,
Palazzo Kira L.,
Parker Samantha A.,
Payman Andre,
Soria Maritza,
Verheyden Lauren,
Vo Vivian T.,
Yin Jennifer,
Calkins Anna L.,
Fuller Amelia A.,
Stokes Grace Y.
Publication year - 2019
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.23256
Subject(s) - peptoid , chemistry , peptidomimetic , combinatorial chemistry , computational biology , biochemistry , peptide , biology
Peptoids are versatile peptidomimetic molecules with wide‐ranging applications from drug discovery to materials science. An understanding of peptoid sequence features that contribute to both their three‐dimensional structures and their interactions with lipids will expand functions of peptoids in varied fields. Furthermore, these topics capture the enthusiasm of undergraduate students who prepare and study diverse peptoids in laboratory coursework and/or in faculty led research. Here, we present the synthesis and study of 21 peptoids with varied functionality, including 19 tripeptoids and 2 longer oligomers. We observed differences in fluorescence spectral features for 10 of the tripeptoids that correlated with peptoid flexibility and relative positioning of chromophores. Interactions of representative peptoids with sonicated glycerophospholipid vesicles were also evaluated using fluorescence spectroscopy. We observed evidence of conformational changes effected by lipids for select peptoids. We also summarize our experiences engaging students in peptoid‐based projects to advance both research and undergraduate educational objectives in parallel.