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Publication year - 2018
Publication title -
biopolymers
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.23064
Subject(s) - cover (algebra) , chemistry , cancer , nanotechnology , cell growth , cancer cell , nanofiber , citation , cell , cancer research , biophysics , computer science , biochemistry , world wide web , biology , materials science , mechanical engineering , engineering , genetics
Conventional cancer therapies, e.g., surgery, chemotherapy and radiation, are not highly cancer‐cell‐specific, and can be harmful to healthy cells. Patwa et al. report magnetic Fe 3 O 4 silk nano‐disc/poly lactic acid electrospun scaffolds as a potential tool to overcome this problem. The magnetic nanofibrous scaffolds are shown to be cytocompatible in vitro , and augment fibroblast adhesion and proliferation. Nanofiber porosity can be tuned by magnetic field‐assisted elecrospinning and used to suppress cancer cell proliferation. Applying an alternating magnetic field achieves hyperthermia‐induced cell killing, and can be combined with the release of the anticancer drug curcumin, providing a synergistic cancer therapy. (DOI: 10.1002/bip.23231 )