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Activity of synthetic peptides against Chlamydia
Author(s) -
Donati Manuela,
Cenacchi Giovanna,
Biondi Roberta,
Papa Valentina,
Borel Nicole,
Vecchio Nepita Edoardo,
Magnino Simone,
Pasquinelli Gianandrea,
Levi Aurora,
Franco Octavio L.
Publication year - 2017
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.23032
Subject(s) - mastoparan , chlamydia , chlamydia trachomatis , in vitro , peptide , microbiology and biotechnology , chemistry , chlamydiaceae , virology , biology , biochemistry , immunology , receptor , g protein
The in vitro activity of six synthetic peptides against 36 strains of Chlamydia from different origins was investigated. Clavanin MO (CMO) proved to be the most active peptide, reducing the inclusion number of all Chlamydia strains from eight different species tested by ≥50% at 10 µg mL −1 . Mastoparan L showed an equal activity against C. trachomatis , C. pneumoniae , C. suis, and C. muridarum, but did not exert any inhibitory effect against C. psittaci , C. pecorum , C. abortus, and C. avium even at 80 µg mL −1 . These data suggest that CMO could be a promising compound in the prevention and treatment of chlamydial infections.