Cover Image, Volume 108, Issue 4 | Zendy

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Cover Image, Volume 108, Issue 4

Publication year - 2017

Publication title -

peptide science

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 0.556

H-Index - 125

eISSN - 1097-0282

pISSN - 0006-3525

DOI - 10.1002/bip.22970

Subject(s) - chemistry , cover (algebra) , citation , volume (thermodynamics) , image (mathematics) , information retrieval , computer science , artificial intelligence , library science , thermodynamics , physics , mechanical engineering , engineering

Steven Cobb et al . report log D values for a series of peptoids that mimic antimicrobial peptides. The log D values were determined using a partition experiment between PBS buffer and octanol, and they provide a measure of the hydrophobicity of the folded state of the peptoids in solution. By comparing the biological activity of peptoids with similar HPLC retention times but different log D values the researchers demonstrate that hydrophobicity, as measured by log D , could offer a useful predictive tool to enable the rational design of biologically active peptoids in the future. (doi: 10.1002/bip.23014 )

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