Cover Image, Volume 108, Issue 3

Sajeevan and Roy report a molecular dynamics simulation of thermal melting and re‐cooling of AuIB, a neurotoxic conopeptide and a highly potent non‐addictive pain reliever, in water and a highly viscous ionic liquid, 1‐butyl‐3‐methylimidazolium chloride, [Im 41 ][Cl]. At 305 K the extensive electrostatic interactions coupled with high viscosity mean the ionic liquid frustrates AuIB, disrupting the native folds. Significantly, the α‐helical motif seen in water is arranged in a less stable 310‐helix. As the temperature is raised, AuIB in [Im 41 ][Cl] approaches the aqueous folded state at 305 K. The image shows the first solvation shell of AuIB in [Im 41 ][Cl] at 400 K. (doi: 10.1002/bip.23009 )