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Cover Image, Volume 108, Issue 1
Publication year - 2017
Publication title -
peptide science
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.22965
Subject(s) - cover (algebra) , internalization , peptide , citation , chemistry , phage display , image (mathematics) , snow cover , computer science , library science , information retrieval , computational biology , artificial intelligence , biochemistry , biology , cell , physics , engineering , snow , meteorology , mechanical engineering
Ernest Giralt and colleagues report on the use of phage display against a human blood‐brain barrier cellular model to identify peptide sequences that translocate across the blood‐brain barrier. Internalization studies with the selected peptide suggest it internalizes through a clathrin‐mediated mechanism and that it increases the uptake of a cargo in endothelial cells.