Premium
Cover Image, Volume 107, Issue 6
Publication year - 2017
Publication title -
biopolymers
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.22951
Subject(s) - chemistry , cover (algebra) , cartilage , denaturation (fissile materials) , volume (thermodynamics) , anhydrous , information retrieval , computer science , thermodynamics , mechanical engineering , anatomy , physics , organic chemistry , engineering , medicine , nuclear chemistry
Typically, thermal denaturation of cartilage and collagen involves changes in the secondary and higher order structures, with the protein chains remaining intact. M. Fields et al . use high temperature Raman spectroscopy to show that hydrolysis and breakage of peptide linkages, caused by reaction with H 2 O molecules released from the tissue at high temperature, accompanies irreversible denaturation of collagen from human cartilage. This occurs even for nominally anhydrous samples, proving strongly bound water molecules remain within the macromolecular matrix. The results will help design routes to materials derived from these biological products and aid surgery involving local heating of cartilage. (DOI: 10.1002/bip.23017 )