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A small molecule— DNA binding landscape
Author(s) -
Chaires Jonathan B.
Publication year - 2015
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.22660
Subject(s) - chemistry , dna , dialysis , sequence (biology) , intercalation (chemistry) , computational biology , small molecule , competition (biology) , molecule , binding site , base pair , biochemistry , ecology , biology , organic chemistry , medicine
ABSTRACT This brief account traces the development of a “competition dialysis” method used to characterize the structural and sequence selectivity of DNA binding compounds. The method was inspired by a simple “differential dialysis” method pioneered by Don Crothers to explore base‐selective intercalator binding. Results from compiled competition dialysis studies provide a small‐molecule DNA binding landscape that shows a rich diversity of interactions and molecular recognition. © 2015 Wiley Periodicals, Inc. Biopolymers 103: 473–479, 2015.