Premium
Azide‐rich peptides via an on‐resin diazotransfer reaction
Author(s) -
Marine Jeannette E.,
Liang Xiaoli,
Song Shuang,
Rudick Jonathan G.
Publication year - 2015
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.22634
Subject(s) - azide , chemistry , bioorthogonal chemistry , amino acid , peptide , combinatorial chemistry , peptide synthesis , sequence (biology) , solid phase synthesis , organic chemistry , click chemistry , biochemistry
ABSTRACT Azide‐containing amino acids are valuable building blocks in peptide chemistry, because azides are robust partners in several bioorthogonal reactions. Replacing polar amino acids with apolar, azide‐containing amino acids in solid‐phase peptide synthesis can be tricky, especially when multiple azide residues are to be introduced in the amino acid sequence. We present a strategy for effectively incorporating multiple azide‐containing residues site‐specifically. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 419–426, 2015.