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Targeting protein−protein interfaces using macrocyclic peptides
Author(s) -
Gao Meng,
Cheng Kui,
Yin Hang
Publication year - 2015
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.22625
Subject(s) - chemistry , expansive , computational biology , small molecule , peptide , protein function , function (biology) , combinatorial chemistry , cyclic peptide , biochemistry , microbiology and biotechnology , biology , gene , materials science , compressive strength , composite material
Protein−protein interactions (PPIs) are critical in numerous biological processes including signaling transduction, function regulations, and disease development. To regulate PPIs has been thought to be challenging due to their highly dynamic and expansive interfacial areas. Nonetheless, successful examples have been reported of targeting PPIs using small molecules, peptides, and proteins. Peptides, especially macrocyclic peptides have proven to be a particularly useful tool to inhibit PPIs for their exquisite potency, stability and selectivity. Herein we review the recent developments of this area of research, focusing on the macrocyclic peptides isolated from natural products, identified from library screening, and rationally designed based on structures, as PPI regulators. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 310–316, 2015.