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Review fifteen years of search for strong nucleosomes
Author(s) -
Trifonov Edward N.,
Nibhani Reshma
Publication year - 2015
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.22604
Subject(s) - nucleosome , dna , centromere , computational biology , dna sequencing , chemistry , sequence (biology) , base pair , histone , genetics , evolutionary biology , biophysics , biology , chromosome , gene
Don Crothers, Mikael Kubista, Jon Widom, and their teams have been first to look for strong nucleosomes, in a bid to reveal the nucleosome positioning pattern(s) carried by the nucleosome DNA sequences. They were first to demonstrate that the nucleosome stability correlates with 10–11 base sequence periodicity, and that the strong nucleosomes localize preferentially in centromeres. This review describes these findings and their connection to recent discovery of the strong nucleosomes (SNs) with visibly periodic nucleosome DNA sequences. © 2014 Wiley Periodicals, Inc. Biopolymers 103: 432–437, 2015.