The response of  DNA  length and twist to changes in ionic strength | Zendy

Manning Gerald S. | Zendy

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The response of DNA length and twist to changes in ionic strength

Author(s) -

Manning Gerald S.

Publication year - 2015

Publication title -

biopolymers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.556

H-Index - 125

eISSN - 1097-0282

pISSN - 0006-3525

DOI - 10.1002/bip.22585

Subject(s) - ionic strength , twist , chemistry , helix (gastropod) , polyelectrolyte , ionic bonding , dna , coupling (piping) , chemical physics , swelling , crystallography , biophysics , composite material , materials science , geometry , ion , polymer , biochemistry , ecology , mathematics , organic chemistry , aqueous solution , snail , biology

We examine twist‐stretch coupling of unconstrained DNA using polyelectrolyte theory as applied to a line‐charge model along with published data on the ionic‐strength dependence of the twist angle. We conclude that twist‐stretch coupling is negative: environmental changes that stretch free DNA, unconstrained by externally applied pulling or twisting forces, are accompanied by unwinding of the double helix. We also analyze a helical model and conclude that the observed unwinding of the DNA helix when ionic strength is decreased is driven by radial swelling of the helix. © 2014 Wiley Periodicals, Inc. Biopolymers 103: 223–226, 2015.

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