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Electrospun tecophilic/gelatin nanofibers with potential for small diameter blood vessel tissue engineering
Author(s) -
Vatankhah Elham,
Prabhakaran Molamma P.,
Semnani Dariush,
Razavi Shahnaz,
Morshed Mohammad,
Ramakrishna Seeram
Publication year - 2014
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.22524
Subject(s) - scaffold , gelatin , thrombogenicity , nanofiber , biomedical engineering , tissue engineering , chemistry , regeneration (biology) , polyurethane , nanotechnology , materials science , surgery , microbiology and biotechnology , biochemistry , thrombosis , medicine , biology , organic chemistry
Tissue engineering techniques particularly using electrospun scaffolds have been intensively used in recent years for the development of small diameter vascular grafts. However, the development of a completely successful scaffold that fulfills multiple requirements to guarantee complete vascular regeneration remains challenging. In this study, a hydrophilic and compliant polyurethane namely Tecophilic (TP) blended with gelatin (gel) at a weight ratio of 70:30 (TP(70)/gel(30)) was electrospun to fabricate a tubular composite scaffold with biomechanical properties closely simulating those of native blood vessels. Hydrophilic properties of the composite scaffold induced non‐thrombogenicity while the incorporation of gelatin molecules within the scaffold greatly improved the capacity of the scaffold to serve as an adhesive substrate for vascular smooth muscle cells (SMCs), in comparison to pure TP. Preservation of the contractile phenotype of SMCs seeded on electrospun TP(70)/gel(30) was yet another promising feature of this scaffold. The nanostructured TP(70)/gel(30) demonstrated potential feasibility toward functioning as a vascular graft. © 2014 Wiley Periodicals, Inc. Biopolymers 101: 1165–1180, 2014.