Enhancement of the helical content and stability induced in a linear oligopeptide by an   i, i + 4 intramolecularly double stapled, overlapping, bicyclic [31, 22, 5]‐( E )ene motif | Zendy

Mazzier Daniela | Zendy; Peggion Cristina | Zendy; Toniolo Claudio | Zendy; Moretto Alessandro | Zendy

Premium

Enhancement of the helical content and stability induced in a linear oligopeptide by an i, i + 4 intramolecularly double stapled, overlapping, bicyclic [31, 22, 5]‐( E )ene motif

Author(s) -

Mazzier Daniela,

Peggion Cristina,

Toniolo Claudio,

Moretto Alessandro

Publication year - 2014

Publication title -

peptide science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.556

H-Index - 125

eISSN - 1097-0282

pISSN - 0006-3525

DOI - 10.1002/bip.22438

Subject(s) - chemistry , intramolecular force , oligopeptide , bicyclic molecule , stereochemistry , helix (gastropod) , peptide , side chain , crystallography , biochemistry , organic chemistry , polymer , biology , ecology , snail

Two consecutive i, i +4 intramolecular, side chain‐to‐side chain, macrocyclizations of different type carried out on a preformed, partially helical peptide result in a largely predominant, double stapled, overlapping, bicyclic [31,22,5]‐(E)ene motif. A detailed ECD and NMR conformational study revealed a significant enhancement of the original helical content and stability, accompanied by an increase of the α‐helix amount over that of the 3 10 ‐helix. © 2013 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 102: 115–123, 2014.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research