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De novo design of functional proteins: Toward artificial hydrogenases
Author(s) -
Faiella Marina,
Roy Anindya,
Sommer Dayn,
Ghirlanda Giovanna
Publication year - 2013
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.22420
Subject(s) - chemistry , computational biology , nanotechnology , combinatorial chemistry , biochemistry , biology , materials science
ABSTRACT Over the last 25 years, de novo design has proven to be a valid approach to generate novel, well‐folded proteins, and most recently, functional proteins. In response to societal needs, this approach is been used increasingly to design functional proteins developed with an eye toward sustainable fuel production. This review surveys recent examples of bioinspired de novo designed peptide based catalysts, focusing in particular on artificial hydrogenases. © 2013 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 100: 558–571, 2013.