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The effects of shear flow on protein structure and function
Author(s) -
Bekard Innocent B.,
Asimakis Peter,
Bertolini Joseph,
Dunstan Dave E.
Publication year - 2011
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.21646
Subject(s) - chemistry , shear (geology) , molecule , function (biology) , shear force , bioprocess , biophysics , mechanics , chemical engineering , classical mechanics , microbiology and biotechnology , composite material , materials science , organic chemistry , physics , engineering , biology
Protein molecules are subjected to potentially denaturing fluid shear forces during processing and in circulation in the body. These complex molecules, involved in numerous biological functions and reactions, can be significantly impaired by molecular damage. There have been many studies on the effects of hydrodynamic shear forces on protein structure and function. These studies are reviewed and the implications to bioprocessing and pathophysiology of certain diseases are discussed. © 2011 Wiley Periodicals, Inc. Biopolymers 95: 733‐745, 2011.