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Protein–protein interactions in transcription: A fertile ground for helix mimetics
Author(s) -
Guarracino Danielle A.,
Bullock Brooke N.,
Arora Paramjit S.
Publication year - 2011
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.21546
Subject(s) - chemistry , computational biology , structural genomics , protein design , protein expression , drug discovery , protein–protein interaction , helix (gastropod) , transcription (linguistics) , protein structure , gene , biochemistry , biology , philosophy , snail , ecology , linguistics
Abstract Designed ligands that inhibit protein–protein interactions involved in gene expression are valuable as reagents for genomics research and as leads for drug discovery efforts. Selective modulation of protein–protein interactions has proven to be a daunting task for synthetic ligands; however, the last decade has seen significant advances in inhibitor design, especially for helical protein interfaces. This review discusses examples of transcriptional complexes targeted by designer helices. © 2010 Wiley Periodicals, Inc. Biopolymers 95: 1–7, 2011.