Premium
Study on syntheses and anticoagulant action of heparin/rare earth nano‐oxides hybrid material
Author(s) -
Wang KunJie,
Li HongXia,
Song YuMin,
Luan NiNa,
Xian Ping
Publication year - 2010
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.21488
Subject(s) - chemistry , heparin , anticoagulant , nano , rare earth , adhesion , chemical engineering , organic chemistry , biochemistry , mineralogy , surgery , medicine , engineering
Four hybrid materials of RE 2 O 3 ‐TDI‐Heparin (TDI = Toluene 2,4–diisocyanate, RE = La, Eu, Nd, Sc) were prepared by the method of graft. The materials were characterized by IR, TG, and SEM, which confirmed that the heparin was grafted on the surface of TDI modified rare earth nano‐oxides. The cell adhesion experiment and the anticoagulant experiment demonstrated that the materials have lower cell toxicity, better cell adhesion as well as better anticoagulant action. In addition, the clotting time of hybrid materials were shortened compared with the heparin. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 887–892, 2010.