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Global cyclotide adventure: A journey dedicated to the discovery of circular peptides from flowering plants
Author(s) -
Gruber Christian W.
Publication year - 2010
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.21414
Subject(s) - disulfide bond , adventure , plant taxonomy , drug discovery , computational biology , chemistry , biology , taxonomy (biology) , nanotechnology , computer science , botany , bioinformatics , artificial intelligence , biochemistry , systematics , materials science
Circular peptides and proteins of great number and diversity have been discovered in bacteria, plants, and animals. Cyclotides—disulfide‐knotted and head‐to‐tail cyclized plant peptides that exhibit various bioactivities—are by far the largest group of circular proteins. Since their first discovery over three decades ago, there has been a lot of progress in the elucidation of structural characteristics and applications of cyclotides as novel peptide drug grafting frameworks, but there is a lack of information about their native occurrence in various plant families. The “global cyclotide adventure” was initiated as a plant collection and analysis project to advance our understanding of the origin and distribution of cyclotides in flowering plants. Here, I will provide a chronological overview of the preparation of this project, including background information on plant taxonomy and morphology, summarize, and comment on the recent progress about the discovery of cyclotide‐producing plants and will give an outlook on the future of cyclotide analysis and further discoveries to be made. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 565–572, 2010. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com