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Enzyme‐instructed self‐assembly of peptide derivatives to form nanofibers and hydrogels
Author(s) -
Gao Yuan,
Yang Zhimou,
Kuang Yi,
Ma ManLung,
Li Jiayang,
Zhao Fan,
Xu Bing
Publication year - 2010
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.21321
Subject(s) - nanofiber , chemistry , peptide , supramolecular chemistry , enzyme , self assembling peptide , self healing hydrogels , drug delivery , in vivo , nanotechnology , in vitro , self assembly , combinatorial chemistry , biochemistry , biophysics , molecule , organic chemistry , materials science , biology , microbiology and biotechnology
The review describes the use of enzyme catalysis and self‐assembly, two essential and ubiquitous processes in biology, to create molecular nanofibers of peptide derivatives at the supramolecular level as potential nanomedicines and biomaterials. In particular, we discuss the use of enzymes to instruct the self‐assembly of small peptide derivatives for hydrogelation, which takes place in vitro or in vivo , extra‐ or intracellularly, as a new strategy to detect the activity of enzymes, screen enzyme inhibitors, type bacteria, develop drug delivery systems, enhance the activity and stability of enzymes, and control the fate of cells. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94:19–31, 2010. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com