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Biomimetic potential of some methacrylate‐based copolymers: A comparative study
Author(s) -
Zecheru Teodora,
Filmon Robert,
Rusen Edina,
Mărculescu Bogdan,
Zerroukhi Amar,
Cincu Corneliu,
Chappard Daniel
Publication year - 2009
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.21286
Subject(s) - methacrylate , copolymer , chemistry , glycidyl methacrylate , methacrylic acid , polymer chemistry , polymer , polymer science , organic chemistry
Preparation of new biocompatible materials for bone recovery has consistently gained interest in the last few decades. Special attention was given to polymers that contain negatively charged groups, such as phosphate, carboxyl, and sulfonic groups toward calcification. This present paper work demonstrates that other functional groups present also potential application in bone pathology. New copolymers of 2‐hydroxyethyl methacrylate with diallyldimethylammonium chloride (DADMAC), glycidyl methacrylate (GlyMA), methacrylic acid (MAA), 2‐methacryloyloxymethyl acetoacetate (MOEAA), 2‐methacryloyloxyethyltriethylammonium chloride (MOETAC), and tetrahydrofurfuryl methacrylate (THFMA) were obtained. The copolymers were characterized by FTIR, swelling potential, and they were submitted to in vitro tests for calcification and cytotoxicity evaluation. GlyMA and MOETAC‐containing copolymers show promising results for further in vivo mineralization tests, as a potential alternative to the classical bone grafts, in bone tissue engineering. © 2009 Wiley Periodicals, Inc. Biopolymers 91: 966–973, 2009. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com