Premium
Artificial collagen gels via self‐assembly of de novo designed peptides
Author(s) -
Yamazaki Chisato M.,
Asada Shinichi,
Kitagawa Kouki,
Koide Takaki
Publication year - 2008
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.21100
Subject(s) - chemistry , self healing hydrogels , peptide , triple helix , disulfide bond , preprint , self assembly , biophysics , helix (gastropod) , nanotechnology , stereochemistry , biochemistry , polymer chemistry , organic chemistry , materials science , ecology , world wide web , computer science , snail , biology
Development of artificial collagens to replace the animal‐derived collagens presents a challenge in the formation of safer and functional biomaterials. We report here the development of collagen‐like gels by means of the self‐assembly of chemically synthesized peptides. The peptides are disulfide‐linked trimers of collagenous Gly‐X‐Y triplet repeats with self‐complementary shapes. Upon cooling the peptide solutions, hydrogels of peptide supramolecules are formed by spontaneous intermolecular triple helix formation. The thermal gel–sol transition appeared to be reversible, and the transition temperatures were found to be tunable by the design of the peptides. Our systems for the formation of artificial collagen‐like gels will offer possibilities for novel types of biomaterials. © 2008 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 90: 816–823, 2008. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com