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Synthesis and in vivo studies of carbohydrate‐based vaccines against group A Streptococcus
Author(s) -
Simerska Pavla,
AbdelAal AbuBaker M.,
Fujita Yoshio,
Batzloff Michael R.,
Good Michael F.,
Toth Istvan
Publication year - 2008
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20992
Subject(s) - epitope , peptide , chemistry , antigen , titer , peptide vaccine , carbohydrate , immune system , preprint , in vivo , glycine , antibody , microbiology and biotechnology , biochemistry , amino acid , immunology , biology , world wide web , computer science
Carbohydrates, as carriers, providing numerous attachment points for the conjugation of peptide antigens and their optimal orientation for the recognition by cells of the immune system, reducing degradation of the attached peptide antigens and many other advantages make carbohydrate‐based vaccine highly promising approach. Multiple copies of a single group A streptococcal (GAS) M protein derived specific peptide antigens (J8 or J14) were coupled onto carbohydrate cores ( D ‐glucose and D ‐galactose) linked to lipophilic amino acids to produce a self‐adjuvanting liposaccharide vaccine against GAS strains. In vivo experiments showed high serum IgG antibody titers against each of the incorporated peptide epitopes, J8 or J14. © 2008 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 90: 611–616, 2008. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com