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Bruce Merrifield and solid‐phase peptide synthesis: A historical assessment
Author(s) -
Mitchell Alexander R.
Publication year - 2008
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20925
Subject(s) - biochemist , preprint , solid phase synthesis , peptide synthesis , chemistry , nanotechnology , peptide , polymer science , combinatorial chemistry , engineering ethics , computer science , engineering , biochemical engineering , biochemistry , world wide web , materials science
Bruce Merrifield, trained as a biochemist, had to address three major challenges related to the development and acceptance of solid‐phase peptide synthesis (SPPS). The challenges were (1) to reduce the concept of peptide synthesis on a insoluble support to practice, (2) overcome the resistance of synthetic chemists to this novel approach, and (3) establish that a biochemist had the scientific credentials to effect the proposed revolutionary change in chemical synthesis. How these challenges were met is discussed in this article. © 2008 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 90: 175–184, 2008. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com