Premium
Structure–activity relationships in β‐defensin peptides
Author(s) -
Taylor Karen,
Barran Perdita E.,
Dorin Julia R.
Publication year - 2008
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20900
Subject(s) - chemistry , defensin , peptide , stereochemistry , computational biology , biochemistry , biology
Abstract The β‐defensins comprise a large family of small cationic antimicrobial peptides widely distributed in plants, mammals and insects. These cysteine rich peptides display multifunctional properties with implications as potential therapeutic agents. Recent research has highlighted their role in both the innate and adaptive immune systems as well as being novel melanocortin ligands. Studies investigating structure and function provide an insight into the molecular basis of their immunological properties. © 2007 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 90: 1–7, 2008. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com