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Simple machine‐assisted protocol for solid‐phase synthesis of depsipeptides
Author(s) -
Spengler Jan,
Koksch Beate,
Albericio Fernando
Publication year - 2007
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20858
Subject(s) - depsipeptide , preprint , robustness (evolution) , chemistry , protocol (science) , combinatorial chemistry , computer science , simple (philosophy) , nanotechnology , stereochemistry , world wide web , biochemistry , materials science , medicine , philosophy , alternative medicine , epistemology , pathology , gene
Abstract A straightforward machine‐assisted protocol for the synthesis of linear depsipeptides is reported. The synthesis was performed on a 433A Peptide Synthesizer (Applied Biosystems) using preprogrammed and optimized modules for Boc chemistry and without any need for hardware modification. The robustness of the protocol was demonstrated with 12 examples of 26‐membered depsipeptides with single and multiple (up to 6) ester backbone substitutions. © 2007 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 88: 823–828, 2007. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com