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EDOTn and MIM, new peptide backbone protecting groups
Author(s) -
IsidroLlobet Albert,
JustBaringo Xavier,
Álvarez Mercedes,
Albericio Fernando
Publication year - 2008
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20823
Subject(s) - preprint , steric effects , chemistry , peptide , combinatorial chemistry , nanotechnology , stereochemistry , polymer science , computer science , world wide web , biochemistry , materials science
In recent years, backbone protection has allowed the synthesis of complex peptidic sequences of high interest by preventing chain aggregation and aspartimides formation. Nevertheless, the backbone protectors currently used have some drawbacks: they are difficult to remove and show high steric hindrance. The new backbone protectors presented in this study (EDOTn and MIM) represent an improvement in both aspects. © 2007 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 90: 444–449, 2008. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley. com