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Protein–protein interactions as targets for small molecule drug discovery
Author(s) -
Fry David C.
Publication year - 2006
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20608
Subject(s) - drug discovery , preprint , chemistry , computational biology , class (philosophy) , drug , protein–protein interaction , small molecule , data science , computer science , world wide web , pharmacology , biochemistry , biology , artificial intelligence
Protein–protein interactions represent a highly populated class of targets for drug discovery. However, such systems present a number of unique challenges. This review presents an analysis of individual protein‐protein interaction systems which have recently yielded success in discovering drug‐like inhibitors. The structural characteristics of the protein binding sites and the attributes of the small molecule ligands are focused upon, in an attempt to derive commonly shared principles that may be of general usefulness in future drug discovery efforts within this target class. © 2006 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 84: 535–552, 2006 This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com