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Synthesis and characterization of the biodegradable polycaprolactone‐graft‐chitosan amphiphilic copolymers
Author(s) -
Yu Haijun,
Wang Wenshou,
Chen Xuesi,
Deng Chao,
Jing Xiabin
Publication year - 2006
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20551
Subject(s) - polycaprolactone , chitosan , amphiphile , chemistry , copolymer , characterization (materials science) , polymer chemistry , chemical engineering , organic chemistry , nanotechnology , polymer , materials science , engineering
Abstract A novel synthetic approach to biodegradable amphiphilic copolymers based on poly (ϵ‐caprolactone) (PCL) and chitosan was presented, and the prepared copolymers were used to prepare nanoparticles successfully. The PCL‐graft‐chitosan copolymers were synthesized by coupling the hydroxyl end‐groups on preformed PCL chains and the amino groups present on 6‐ O ‐triphenylmethyl chitosan and by removing the protective 6‐ O ‐triphenylmethyl groups in acidic aqueous solution. The PCL content in the copolymers can be controlled in the range of 10‐90 wt %. The graft copolymers were thoroughly characterized by 1 H NMR, 13 C NMR, FT‐IR and DSC. The nanoparticles made from the graft copolymers were investigated by 1 H NMR, DLS, AFM and SEM measurements. It was found that the copolymers could form spherical or elliptic nanoparticles in water. The amount of available primary amines on the surface of the prepared nanoparticles was evaluated by ninhydrin assay, and it can be controlled by the grafting degree of PCL. © 2006 Wiley Periodicals, Inc. Biopolymers 83:233–242, 2006 This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com