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UV‐resonance Raman spectroscopic study of human plasma of healthy donors and patients with thrombotic microangiopathy
Author(s) -
Harz M.,
Claus R. A.,
Bockmeyer C. L.,
Baum M.,
Rösch P.,
Kentouche K.,
Deigner H.P.,
Popp J.
Publication year - 2006
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20489
Subject(s) - chemistry , raman spectroscopy , human plasma , thrombotic microangiopathy , plasma , blood plasma , resonance (particle physics) , resonance raman spectroscopy , microangiopathy , biochemistry , chromatography , pathology , endocrinology , medicine , physics , disease , quantum mechanics , optics , diabetes mellitus , particle physics
Various diseases shift the composition of human plasma; hence, the relative quantification of plasma constituents offers the opportunity to use the dynamic and complex composition of plasma to gain information on novel diagnostic and prognostic factors. Since plasma contains, besides water, mostly proteins, UV‐resonance Raman spectroscopy (UVRR) seems to be a suitable method for investigating plasma. With this method the signals of aromatic amino acids and proteins are selectively enhanced. In this study an UV‐resonance Raman approach was used for the investigation of human plasma of healthy volunteers and patients with thrombotic microangiopathy. For comparison, selected plasma components were analyzed for a more detailed characterization of cryoprecipitates from human plasma. © 2006 Wiley Periodicals, Inc. Biopolymers 82:317–324, 2006 This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com