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Rational design and synthesis of a double‐stranded DNA–binder library
Author(s) -
S̆ebestík Jaroslav,
Hlavác̆ek Jan,
Stibor Ivan
Publication year - 2006
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20487
Subject(s) - chemistry , dna , peptide , rational design , combinatorial chemistry , double stranded , block (permutation group theory) , stereochemistry , computational biology , biochemistry , nanotechnology , biology , combinatorics , mathematics , materials science
Described is a computer‐assisted rational design of a DNA–bis‐intercalator peptide library. The peptide library of 250 members was prepared and the most powerful binder identified. A value of the binding constant is almost two orders of magnitude higher than that of starting building block‐9‐aminoacridine. The binder affinity found toward calf thymus DNA is 30‐fold of that of human prion peptide 106–126. © 2006 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 84: 400–407, 2006 This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com