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C α ‐Tetrasubstituted amino acid based peptides in asymmetric catalysis
Author(s) -
Licini Giulia,
Bonchio Marcella,
Broxterman Quirinus B.,
Kaptein Bernard,
Moretto Alessandro,
Toniolo Claudio,
Scrimin Paolo
Publication year - 2005
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20356
Subject(s) - chemistry , catalysis , amino acid , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry
C α ‐tetrasubstituted α‐amino acids constitute a powerful tool for controlling the conformation of short peptide sequences. Chiral peptides may be used in stereoselective reactions both for asymmetric induction and in kinetic resolution. By reviewing recent data from our own laboratories and by presenting new results on the stereoselective oxidation of chalcone to the corresponding oxide, this contribution shows that the control of peptide conformation is a critical issue in order to achieve successful stereoselective catalysis. © 2005 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 84: 97–104, 2006 This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com