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Abstracts of Poster Section C
Author(s) -
WRIGHT K,
SARCIAUX M,
WAKSELMAN M,
MAZALEYRAT JP,
CRISMA M,
FORMAGGIO F,
PEGGION C.,
TOFFOLETTI A,
CORVAJA C,
TONIOLO C
Publication year - 2005
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20325
Subject(s) - section (typography) , citation , library science , information retrieval , world wide web , computer science , chemistry , operating system
The spin-labelled, cyclic, chiral beta-amino acids cis-beta-TOAC and trans-beta-TOAC, have been synthesised in an enantiomerically pure form by amination of 3-carboxymethyl-1-oxyl-2,2,6,6-tetramethyl-4-piperidone with (R)- or (S)-alfa-methyl-benzylamine, followed by reduction with NaBH3CN/CH3COOH or NaBH4/(CH3)2CHCOOH. The 3D-structure of the hexapeptide 1, prepared by 4+2 segment coupling in solution, has been preliminarily analyzed by spectroscopic techniques