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Structural chemoproteomics and drug discovery
Author(s) -
Shin Dongkyu,
Heo YongSeok,
Joo Lee Kyung,
Min Kim Cheol,
Min Yoon Jung,
Il Lee Jae,
Hyun YoungLan,
Ho Jeon Young,
Gyu Lee Tae,
Myung Cho Joong,
Ro Seonggu
Publication year - 2005
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20263
Subject(s) - drug discovery , chemistry , computational biology , drug , virtual screening , lead (geology) , nanotechnology , biochemical engineering , pharmacology , biochemistry , biology , engineering , paleontology , materials science
Our laboratories have developed several technologies to accelerate drug discovery process on the basis of structural chemoproteomics. They include SPS ™ technology for the efficient determination of protein structures, SCP ™ technology for the rapid lead generation and SDF ™ technology for the productive lead optimization. Using these technologies, we could determine many 3D structures of target proteins bound with biologically active chemicals including the structure of phosphodiesterase 5/Viagra complex and obtain highly potent compounds in animal models of obesity, diabetes, cancer and inflammation. In this paper, we will discuss concepts and applications of structural chemoproteomics for drug discovery. © 2005 Wiley Periodicals, Inc. Biopolymers (Pept Sci), 2005