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1 H‐NMR study of the inclusion processes for α‐ and γ‐cyclodextrin with fenbufen
Author(s) -
Bratu I.,
GaviraVallejo J. M.,
Hernanz A.
Publication year - 2005
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20245
Subject(s) - chemistry , cyclodextrin , supramolecular chemistry , aqueous solution , stoichiometry , nuclear magnetic resonance spectroscopy , beta cyclodextrins , inclusion compound , inclusion (mineral) , computational chemistry , stereochemistry , molecule , organic chemistry , mineralogy
1 H‐NMR spectra of aqueous solutions of fenbufen and two cyclodextrins (α‐ or γ‐cyclodextrin, respectively) mixtures confirm the formation of an inclusion complex if γ‐cyclodextrin is used, whereas in the case of α‐cyclodextrin no inclusion complex was obtained. The stoichiometry of the fenbufen/γ‐cyclodextrin complex is of the [2:1] type. The geometry of this supramolecular architecture was established through MM+ molecular mechanics calculations. © 2005 Wiley Periodicals, Inc. Biopolymers 77: 361–367, 2005