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Artificial diiron proteins: From structure to function
Author(s) -
Calhoun Jennifer R.,
Nastri Flavia,
Maglio Ornella,
Pavone Vincenzo,
Lombardi Angela,
DeGrado William F.
Publication year - 2005
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20230
Subject(s) - chemistry , protein design , function (biology) , structure function , metalloprotein , computational biology , protein structure , biochemistry , enzyme , microbiology and biotechnology , physics , biology , particle physics
De novo protein design provides an attractive approach for the construction of models to probe the features required for the function of complex metalloproteins. These minimal models contain the essential elements believed necessary for activity of the protein. In this article, we summarize the design, structure determination, and functional properties of a family of artificial diiron proteins. © 2005 Wiley Periodicals, Inc. Biopolymers (Pept Sci), 2005