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Solid‐phase synthesis of second‐generation polyproline dendrimers
Author(s) -
Sanclimens Glòria,
Crespo Laia,
Giralt Ernest,
Royo Miriam,
Albericio Fernando
Publication year - 2004
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20125
Subject(s) - polyproline helix , dendrimer , chemistry , solid phase synthesis , branching (polymer chemistry) , proline , phase (matter) , combinatorial chemistry , amino acid , organic chemistry , biochemistry , peptide
Abstract Second‐generation dendrimers have been prepared on solid phase by successive additions of branched polyproline building blocks starting from two different branching units anchored to the solid support. The preparation of Pro‐rich building blocks was carried out by stepwise solid‐phase synthesis and their iterative addition was performed by a convergent approach, also using solid‐phase synthesis. cis ‐4‐Amino‐ L ‐proline and imidazolidine‐2‐carboxylic acid were used as branching units due to their structural resemblance to proline. The optimized strategy allowed the target compounds to be obtained with high purities without the need for purification steps. © 2004 Wiley Periodicals, Inc. Biopolymers (Pept Sci), 2004