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Novel polyelectrolyte carboxymethyl konjac glucomannan–chitosan nanoparticles for drug delivery. I. Physicochemical characterization of the carboxymethyl konjac glucomannan–chitosan nanoparticles
Author(s) -
Du Jian,
Sun Rui,
Zhang Sheng,
Zhang LiFang,
Xiong ChengDong,
Peng YuXing
Publication year - 2005
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20119
Subject(s) - polyelectrolyte , chitosan , chemistry , zeta potential , glucomannan , nanoparticle , aqueous solution , drug delivery , bovine serum albumin , fourier transform infrared spectroscopy , nuclear chemistry , chemical engineering , drug carrier , chromatography , polymer , organic chemistry , biochemistry , engineering
Carboxymethyl konjac glucomannan–chitosan (CKGM–CS) nanoparticles, which are well dispersed and stable in aqueous solution, were spontaneously prepared under very mild conditions via polyelectrolyte complexation. The physicochemical properties of the nanoparticles were identified by Zetasizer 3000 and Fourier transform infrared. It was found that at various CKGM and CS concentrations the particles ranged in size from approximately 50 to 1200 nm, and the zeta potential from 15 to 45 mV. By changing pH value of the medium and increasing the concentration of salt, the mean size of the particles increased and the zeta potential decreased. Also, investigations on the encapsulation efficiency of the bovine serum albumin loaded CKGM–CS nanoparticles were also undertaken. This nanoparticulate system driven by complex formation shows potential as an advanced drug delivery system for water‐soluble drugs. © 2005 Wiley Periodicals, Inc. Biopolymers, 2005