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An algebraic model of RNA duplex formation
Author(s) -
Bashford J. D.,
Jarvis P. D.
Publication year - 2004
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.20022
Subject(s) - duplex (building) , equivalence (formal languages) , chemistry , oligomer , rna , algebraic number , oligonucleotide , base pair , simple (philosophy) , algebraic properties , thermodynamics , statistical physics , dna , pure mathematics , physics , polymer chemistry , mathematics , biochemistry , mathematical analysis , epistemology , philosophy , gene
We propose a simple algebraic description of the two‐body interactions of bases in RNA thermodynamics showing in detail qualitative equivalence with conventional nearest‐neighbor models. The process of obtaining base content, polymer, and oligomer parameters is illustrated, and for duplexes containing Watson–Crick pairs, fits to oligonucleotide duplex heat‐of‐formation data are shown to be statistically equivalent to existing models. © 2004 Wiley Periodicals, Inc. Biopolymers, 2004