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Laser Raman spectroscopic studies of poly(r‐cytidylic acid) and poly(r‐adenylic acid) complexes with poly( L ‐lysine) and poly( L ‐arginine)
Author(s) -
Hernández Luis A.,
Vieta René S.,
Jao TzeChi
Publication year - 1980
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1980.360191003
Subject(s) - polynucleotide , lysine , arginine , chemistry , stacking , raman spectroscopy , amino acid , polymer chemistry , stereochemistry , biochemistry , organic chemistry , physics , optics
Complexes of polyribocytidylic acid and polyriboadenylic acid with poly( L ‐lysine) and poly( L ‐arginine) were studied by Raman spectroscopy. The backbones of both polynucleotides are distorted by poly( L ‐arginine). On the other hand, poly( L ‐lysine) could distort the backbone of polyriboadenylic acid but not that of polyribocytidylic acid. In general, poly( L ‐arginine) can increase the order of the base stacking, while poly( L ‐lysine) causes disordering in the base stacking.