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Synthesis and ordered structure of amphipatic block copolymers with a saccharide and a peptide block
Author(s) -
Douy André,
Gallot Bernard
Publication year - 1980
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1980.360190305
Subject(s) - lamellar structure , copolymer , chemistry , block (permutation group theory) , peptide , block structure , polymer chemistry , stereochemistry , crystallography , biochemistry , polymer , organic chemistry , materials science , core (optical fiber) , geometry , mathematics , composite material
Amphipatic block copolymers (OβEb) with a hydrophilic saccharide block and a hydrophobic polypeptide block were synthesized. In these copolymers the saccharide block is the glyco‐amino acid Oβ from ovomucoid and the peptide block (Eb) is a poly(γ‐benzyl‐ L ‐glutamate) block. Copolymers OβEb exhibit, in the solid state and in Me 2 SO concentrated solutions, mesomorphic lamellar structures where the polypeptide chains are in an α‐helical conformation. Depending on the molecular weight of the polypeptide block, three types of lamellar structures are obtained, and they differ by the mode of organization of the polypeptide chains in their lamellae and by the T or Y conformation of the saccharide block.