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Study of the rotational diffusion properties of peptides in solution
Author(s) -
Bleich H. E.,
Glasel J. A.,
Latina M.,
Visintainer J.
Publication year - 1979
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1979.360181113
Subject(s) - chemistry , rotational diffusion , anisotropy , relaxation (psychology) , diffusion , lattice (music) , spin–lattice relaxation , work (physics) , computational chemistry , chemical physics , nuclear magnetic resonance , crystallography , thermodynamics , molecule , organic chemistry , physics , quantum mechanics , psychology , social psychology , nuclear quadrupole resonance , acoustics
In this paper we examine the theory and method for obtaining rotational diffusion coefficients for peptides in dilute solution from 13 C‐nmr spin‐lattice relaxation data. We show that even for the case of nearly equal observed relaxation times of chemically and magnetically nonequivalent alpha‐carbons marked rotational anisotropy will be the usual case. We describe two interactive, minicomputer programs which are of general use in this type of work. The implications of this study on spectral density‐based conformational determinations of peptides is discussed.