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Diffusion–collision model for protein folding
Author(s) -
Karplus Martin,
Weaver David L.
Publication year - 1979
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1979.360180608
Subject(s) - chemistry , coalescence (physics) , collision , diffusion , rotational diffusion , folding (dsp implementation) , protein folding , chemical physics , surface diffusion , classical mechanics , mechanics , thermodynamics , physics , molecule , adsorption , engineering , biochemistry , computer security , organic chemistry , astrobiology , computer science , electrical engineering
The basic equations for the elementary step in the diffusion–collision–coalescence model of protein folding are derived for the case of two radially diffusing spherical microdomains. Refinements and biological implications of the mechanism are considered; included are detailed discussions of the parameters of the model, the possibilities of rotational diffusion and surface diffusion in one or two dimensions, the nature of the microdomains, and the application of the model to protein unfolding.