Premium
The infuence of interchain compositional heterogeneity on the conformation in random copolymers of γ‐benzyl‐ L ‐glutamate and L ‐valine
Author(s) -
Deshmane S.,
Hayashi T.,
Sederel W.,
Anderson J. M.
Publication year - 1978
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1978.360171208
Subject(s) - copolymer , chemistry , methylene , guanidinium chloride , monomer , polymer chemistry , benzene , solvent , reactivity (psychology) , chloride , composition (language) , kinetics , helix (gastropod) , organic chemistry , polymer , medicine , ecology , linguistics , philosophy , alternative medicine , pathology , snail , biology , enzyme , physics , quantum mechanics
Variation in the solvent used for the copolymerization of γ‐benzyl‐ L ‐glutamate and L ‐valine N ‐carboxyanhydrides provides copolymers which have variable interchain compositions, and this variation in interchain compositional heterogeneity is reflected in the solid‐state conformations of the respective copolymers. Poly[Glu(OBzl) 29 Val 71 ] prepared in dioxane exhibits a β‐structure, whereas a copolymer of the same average composition prepared in benzene/methylene chloride shows predominantly an β‐helix conformation with a small amount of β‐structure. The use of the monomer reactivity ratio permits the calculation of the average and incremental copolymer compositions at any conversion; thus, correlations between conformation and interchain compositional heterogeneity can be made. In general, copolymers prepared in dioxane show a greater distribution of chain composition and therefore permit a wider variety of conformation than copolymers prepared in benzene/methylene chloride under identical conditions.