Premium
Rotating frame spin‐lattice relaxation experiments and the problem of intramolecular motions of peptides in solution
Author(s) -
Bleich Hermann E.,
Glasel Jay A.
Publication year - 1978
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1978.360171012
Subject(s) - intramolecular force , chemistry , lattice (music) , amide , relaxation (psychology) , peptide , crystallography , chemical physics , molecular physics , computational chemistry , stereochemistry , physics , organic chemistry , psychology , social psychology , biochemistry , acoustics
The application of rotating frame spin‐lattice relaxtion to the determination of the intramolecular motions in peptides is discussed, and results are presented on the application of 13 C T 1 p to peptide microdynamics in solution. The effective molecular rotational reorientation times at the amide and amino nitrogens may be derived from appropriate data on T 1 p of the carbons adjacent to them. We also show by theoretical caculations that 1 H and 13 C T 1 p experiments of suitable 2 H and 15 N substituted peptides will allow intramolecular main‐ and sidechain motions, characterized by times in the range 10 −1 –10 −6 sec, to be investigated.