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The effect of homologous amino acid replacement on the conformation of oligopeptides. I. Synthesis of co‐oligopeptides containing methionine and valine
Author(s) -
Becker Jeffrey M.,
Naider Fred
Publication year - 1978
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1978.360170912
Subject(s) - oligopeptide , chemistry , valine , methionine , amino acid , peptide synthesis , homologous series , sodium , stereochemistry , organic chemistry , peptide , biochemistry
The preparation of a series of co‐oligopeptides Boc‐Val‐Met n ‐OMe( n = 1–6), as sell as Boc‐Met 3 ‐Val‐et 2 ‐OMe and Boc‐Met 3 ‐Val‐Met 3 ‐Ome, is described. The synthesis was carried out by a classic method employing the mixed anhydride procedure (isobutylchloroformate) for all coupling reactions. All oligopeptides after purification were homogenous on silica thin layers and gave correct elemental analysis. They were judged to be optically pure using molar rotation studies at the sodium D line.