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Synthesis of sequential polypeptides containing lysine and tyrosine
Author(s) -
St. Pierre S.,
Ingwall R. T.,
Goodman M.
Publication year - 1978
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1978.360170802
Subject(s) - chemistry , succinimide , lysine , monomer , polymerization , tyrosine , polymer chemistry , condensation , stereochemistry , amino acid , organic chemistry , biochemistry , polymer , physics , thermodynamics
Sequential polypeptides with the repeating units L ‐tyrosyl‐ L ‐lysyl, L ‐tyrosyl‐( L ‐lysyl) 2 , and L ‐tyrosyl‐( L ‐lysyl) 3 have been synthesized by solution polymerization of the N ‐hydroxy‐succinimide esters of the corresponding di‐, tri‐, and tetrapeptides. The monomers for the polytripeptide and polytetrapeptide were prepared by fragment condensation, using the mixed carbonic anhydride coupoling method. Moderately high molecular weight polypeptides were obtained.